Will Tadalafil Make My Penis Bigger?
Numerous factors such as ageing, weight, diabetes mellitus, cardiovascular disorders, smoking, high blood pressure, and alcohol use can contribute to the development of erectile dysfunction (ED).
Owing to the various physical and psychosocial aspects of ED, treatment of ED extends beyond improving erectile function (EF) response and satisfaction.
Since the development of PDE-5 inhibitors, the use of the drugs was acknowledged to be the first line treatment option for men suffering from ED.
Prescribing specialists and patients are facing a choice between 4 different drugs: Sildenafil, Tadalafil, Vardenafil and Avanafil, with a close focus on the underlying conditions of each patient and the best tolerability.
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Why Tadalafil?
Compared with other phosphodiesterase types 5 (PDE5) inhibitors like sildenafil (Viagra) or vardenafil (Levitra), Tadalafil has the advantage of a longer half-life that provides a therapeutic window of 36 hours, hence the name of the ”weekend pill”.
Patients who have tried Tadalafil reported fewer side effects and long-lasting effects than patients who have tried other phosphodiesterase- type 5 -inhibitors.
Due to its effectiveness that lasts up to 36 hours, Tadalafil could offer nearly continuous coverage when taken on a regular basis, allowing patients and their partners to choose freely when to have sexual activities without the need of timing it.
Tadalafil important facts:
Tadalafil received the approval to be used in Europe in 2002 and in the United States of America in 2003.
When a man is sexually stimulated, his body’s normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, Tadalafil helps to maintain an erection by increasing blood flow to the penis. Without physical action to the penis, such as that occurring during sexual intercourse, Tadalafil will not work to cause an erection.
Tadalafil, with on-demand (PRN) and once-daily (OAD) dosing regimens, has demonstrated efficacy and safety in the treatment of ED in numerous clinical trials.
For patients planning to have sex on a regular basis or a planned schedule, Tadalafil on as needed dose can be the thing. Tadalafil on as needed dose is available at multiple strengths( 10 mg and 20 mg) and different quantities (packs of 4, 8, 12, 16, 32 or 64 tablets).
For spontaneous patients that won’t plan their activity around the pill, once-a-day Tadalafil makes it a perfect choice.
The once-a day Tadalafil comes in dosages of 2,5 mg and 5 mg.
Which is better, daily or on demand use?
After reviewing the results of 4354 men with ED using both regimens of tadalafil, the authors Brock et al 5 concluded that Tadalafil OAD and PRN regimens showed both efficacy in patients with ED. No clinical populations of patients with ED seemed to benefit overwhelmingly from one dose regimen over the other.
Tolerability of Tadalafil 
For Tadalafil, generally mild and self-limited adverse reactions were reported.
- The most common side effects of Tadalafil are: headaches, indigestion, back pain, muscle aches, flushing, and a stuffy or a runny nose.
Severe side effects that are a signal for stopping immediately the administration of Tadalafil are the following: allergic reactions including rashes, chest pain, priapism, an erection that lasts more than 4 hours, sudden loss of vision in one or both eyes, which could be a sign of non-arthritic anterior ischemic optic neuropathy (NAION), sudden decrease or loss of hearing (sometimes with ringing in the ears and dizziness) - Uncommon side effects (reported in 1 to 10 in every 10000 patients) include: dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired.
- Rare side effects (reported in 1 to 10 in every 1000 patients) that have been reported are: fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, itchy red welts on the surface of the skin, penile bleeding, presence of blood in semen and increased sweating.
The tolerability of Tadalafil must be evaluated when choosing a dose regimen. Usually, the prescribed once-a-day dose is 5 mg, but in the unlikely event that some unpleasant reactions occur, the dose must be down titrated to 2,5 mg.
The same applies for the as needed dose. You should start with the 10 mg regimen, and use a lower dose if you feel uncomfortable. Or, you can increase the dose to 20 mg based upon the efficacy and tolerability.
Which drugs could influence the action of Tadalafil?
Tadalafil is contraindicated to be administrated when you are suffering from angina pectoris and you are administering any form of organic nitrates (nitroglycerine, isosorbide dinitrate, isosorbide mononitrate, or nitroprusside), because it increases the hypotensive effect of the nitrates. Using Tadalafil with this type of drugs may cause an excessive decrease of blood pressure and finally, cardiovascular colaps.
Tadalafil co-administrated with alpha androgenic blocking agents (doxazosin, tamsulosin, afluzosin) is not recommended because both drugs are vasodilators with blood pressure lowering effect.
Hypotensive effects of riociguat, a drug used to treat pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, have been shown to be increased when administering Tadalafil.
Other drugs may influence the pharmacokinetic properties of Tadalafil
Antiacids modify the rate of absorbtion;
Therapeutic effects and side effects could be increased by inhibitors of CYP3A4, the enzyme involved in Tadalafil metabolism, such as ketoconazole or HIV protease inhibitors;
The antibiotic rifampicin, a CYP3A4 inducer reduces the effects of Tadalafil.
Tadalafil is contraindicated to be concomitantly taken with Cialis, because both drugs contain the same active substance and their concomitant use might lead to an overdose.
Patients with cardiac disorders should be very carefully when taking Tadalafil. They should report to the physician or pharmacist all the heart medicines they are taking for a proper evaluation of the risk/benefit ratio.
To start a consultation for you ED evaluation or to see if Tadalafil is the appropriate treatment for you, please contact us on our website here:
https://www.menspharmacy.co.uk/contact-us/
If you are intending to use Tadalafil for the first time, or if you have questions related to its side-effects, please address directly to our pharmacy and to our doctor at phone number 0161 707 6800,
Remember that you must have a prescription when ordering Tadalafil.
If you are a first time user, you must complete an online questionnaire and afterwards a GMC regulated doctor will issue a prescription that allows you to acquire Tadalafil in an efficient, safe and regulated manner.
So, what should be my real expectations after taking Tadalafil for the first time, will Tadalafil make my penis bigger?
Tadalafil will not make your penis bigger and neither won’t decrease premature ejaculation.
It will, however, help you get an satisfactory erection. Tadalafil will also make possible a few more erections during the interval of 36 hours post dose.
What if I miss a dose?
If you are taking this medication on a daily schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
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References:
- Derby CA, Mohr BA, Goldstein I, et al. Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology 2000;56:302-306.
- Fonseca J, Tomada N, Magalhães A, et al. Effect of aging and cardiovascular risk factors on receptor tie1 expression in human erectile tissue. J Sex Med 2015;12:876-886.
- http://www.cialis-database.com/description/the-history-of-cialis.html history
- Porst H, Padma-Nathan H, Giuliano F, Anglin G, Varanese L, Rosen R. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial., J Urol. 2003 Jul; 62(1):121-5; discussion 125-6. PubMed PMID: 12837435;
- Brock, G., Ni, X., Oelke, M., Mulhall, J., Rosenberg, M., Seftel, A., … Barry, J. (2016). Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil
- Databases. The Journal of Sexual Medicine, 13(5), 860–875. doi:10.1016/j.jsxm.2016.02.171
- https://www.medicines.org.uk/emc/product/8636/smpc
Mens Pharmacy is not liable for the currency or accuracy of the information contained in this blog post. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected].